Acanthus ilicifolius Linn. (Acanthaceae) is relatively lesser-known, yet important medicinal plant of Herbal Materia Medica. The plant is used in traditional systems of medicine, including Traditional Indian Medicine (TIM) or Ayurveda and Traditional Chinese Medicine (TCM). The plant is reported to contain phytochemicals including alkaloid and wide range of glucosides (lignan and phenylethanoid). In traditional medicine, the plant is used in the treatment of diseases ranging from snake bite to skin diseases. Laboratory investigations on extracts of the plant have demonstrated significant pharmacological activities like antioxidant, anticarcinogenic, anti-osteporotic and hepatoprotective. The review analyses traditional medicinal usage, and phyto-pharmacological investigations done on the medicinal plant.Keywords: Acanthus ilicifolius, traditional medicine, phytochemistry, pharmacology, glucoside