The Illinois Mathematics and Science Academy (IMSA) serves as a catalyst to improve teaching and learning in mathematics and science. This article describes IMSA initiatives that have statewide impact, including the IMSA Excellence 2000+ (E2K+) Program, which is designed to enrich mathematics and science exploration among middle school students. E2K+ addresses Illinois State Board of Education (ISBE) learning standards and recommended National Science Foundation (NSF) Science, Technology, Engineering, and Mathematics (STEM) learning outcomes