SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Patel, Ashwin I.Ashwin

Shah, Anwar

Sheth, Jayesh J.

Verhest, Alain

VinSheth, Frenny J.

Present study consists of cytogenetic evaluation in 141 cases referred
to our centre for various leukemias. This includes 110 cases of CML, 10
of ALL, 16 of AML (M3), 2 of AML(M2), 2 of MDS &amp; 1 of CMML. The
conventional cytogenetic study was carried out in all the cases using G
Banding technique. Of the 141 patients studied, 17 patients showed
secondary chromosomal alterations along with primary chromosomal
alterations. In two patients of CML with secondary chromosomal
alteration t(4:9:22), molecular cytogenetic technique (FISH) has been
carried out which has confirmed the primary observations revealed by
the conventional cytogenetic technique. Other secondary alterations
were numerous and would have been missed if only FISH or PCR technique
would have been used for diagnosis. We observed from our study that
advanced molecular techniques like FISH &amp; PCR cannot replace the
conventional cytogenetic study but are useful as supportive and
confirmative diagnostic tools

Frenny J. VinSheth

Jayesh J. Sheth

Ashwin I. Patel

Ami D. Shah

Alain Verhest

University of Toronto Research Repository

Usefulness of Cytogenetics in Leukemias

DI-fusion

Usefulness of cytogenetics in leukemias

TSpace Repository

Usefulness of cytogenetics in leukemias

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