The purpose of part one of this thesis was to synthesize previous research and information about cancer, children and cancer, exercise and cancer, and the long and short-term effects of cancer. After synthesizing previous research, the second part of this thesis was to integrate that research and create a set of safe and effective physical activity guidelines for children during and after cancer treatment. Lastly, a sample exercise prescription was created. This prescription was tailored for a fictional young child in a pediatric cancer rehabilitation program. The design of the pediatric cancer rehabilitation program was based on meeting the needs of a child, physically, emotionally, and socially