This paper proposes the minimum power configuration (MPC) approach to energy conservation in wireless sensor networks. In sharp contrast to earlier research that treats topology control, power-aware routing, and sleep management in isolation, MPC integrates them as a joint optimization prob-lem in which the power configurationof a network consists of a set of active nodes and the transmission powers of the nodes. We show through analysis that the minimum power configu-ration of a network is inherently dependent on the data rates of sources. We propose several approximation algorithms with provable performance bounds compared to the optimal solu-tion, and a practical Minimum Power Configuration Protocol (MPCP) that can dynamically (re)configure a network to mini-mize the energy consumption based on current data rates. Sim-ulations based on realistic radio models of the Mica2 motes show that MPCP can conserve significantly more energy than existing minimum power routing and topology control protocols