A regional workshop sponsored by the National Science Foundation, Arlington, Virginia, September 29-30, 2016. To determine what needs and opportunities might exist for mid-scale instrumentation (MSI), two workshops were held in fall of 2016 to explore opportunities within the discipline that could be provided by such investment. One workshop was convened to explore the need for co-localization of existing instrumentation at a regional or cyber-enabled facilities (addressed in this report, “Mid-Scale Instrumentation: Regional Facilities to Address Grand Challenges in Chemistry”). In this report, we identify different areas where investment in such MSI facilities would be highly beneficial. These appear as six “grand challenges” that can be summarized here as follows: 1. Structure and dynamics at interfaces 2. Highly parallel chemical synthesis and characterization 3. Transient intermediates 4. New science arising from the characterization of heterogeneous mixtures 5. Multi-scale dynamics of complex systems: integrating transport with reaction 6. Structure-function relationship in disordered and/or heterogeneous system
