Assessing molecular variability in cancer genomes

Abstract

The dynamics of tumour evolution are not well understood. In this paper we provide a statistical framework for evaluating the molecular variation observed in different parts of a colorectal tumour. A multi-sample version of the Ewens Sampling Formula forms the basis for our modelling of the data, and we provide a simulation procedure for use in obtaining reference distributions for the statistics of interest. We also describe the large-sample asymptotics of the joint distributions of the variation observed in different parts of the tumour. While actual data should be evaluated with reference to the simulation procedure, the asymptotics serve to provide theoretical guidelines, for instance with reference to the choice of possible statistics.Comment: 22 pages, 1 figure. Chapter 4 of "Probability and Mathematical Genetics: Papers in Honour of Sir John Kingman" (Editors N.H. Bingham and C.M. Goldie), Cambridge University Press, 201