The purpose of this study was to examine whether targeted cognitive-based reading interventions are more effective than traditional evidence-based Tier II reading interventions. Ninety students who performed in the lowest third on a state reading test from a rural school district in Virginia were placed into three groups: 1) students who received traditional evidence-based reading interventions, 2) students whose teachers were trained in Cattell-Horn-Carroll theory and whose teacher chose an intervention that he/she thought would be most tailored to the student’s cognitive needs, 3) students who were tested using the Woodcock Johnson III Tests of Cognitive Abilities (WJ-III) and were given interventions tailored to their cognitive profile. The mean reading scores on a posttest were compared. Contrary to the research hypotheses, results indicated that there were no significant differences between groups