Measures of Additive Interactionand Effect Direction

Abstract

Measures for additive interaction are defined using risk ratios. These ratios need to be modeled so that all combinations of the exposures are harmful, as the scale between protective and harmful factors differs. This remodeling is referred to as recoding. Previously, recoding has been thought of as random. In this paper, we will examine and discuss the impact of recoding in studies with small effect sizes, such as genome wide association studies, and the impact recoding has on significance testing.QC 20190930</p