Teekamp, Naomi

University of Groningen

   University of GroningenProtein delivery from polymeric matricesTeekamp, NaomiIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2018Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Teekamp, N. (2018). Protein delivery from polymeric matrices: From pre-formulation stabilization studies tosite-specific delivery. [Groningen]: Rijksuniversiteit Groningen.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 12-11-2019PROPOSITIONS1. Addition of the polysaccharide pullulan to the gold standard in sugar glass technology, the disaccharide trehalose, substantially improves the performance at humid conditions. (this thesis)2. Hot melt extrusion can be applied for the production of protein-containing formulations by using low temperature processable polymers and sugar glass technology. (this thesis)3. Systemic delivery of PDGFb-receptor directed proteins using subcutaneously administered microspheres composed of phase-separated multi-block copolymers does not compromise their targeting properties. (this thesis)4. Efficient delivery of drugs to diseased tissue can be achieved by utilizing the selectivity of proteins in the design of the drug carrier. 5. The complexity of therapeutically active proteins does not allow the use of model proteins during formulation development.6. The reason that the implementation of Paul Ehrlich’s concept of the Magic Bullet will never reach perfection is enclosed in its name.7. Shared first authorship is not a halving of the work, but a synergy resulting in interdisciplinary research at its best.8. Even the most well-prepared are not prepared for the amount of backup plans necessary during a PhD project.9. De essentie van de Indische keuken is te vatten in wat heet heet15346-teekamp-propositions.indd   1 04/03/2018   20:11Naomi TeekampPROTEIN DELIVERY fromPOLYMERIC MATRICESFrom pre-formulation stabilization studies to site-specific delivery15346-teekamp-propositions.indd   2 04/03/2018   20:11

Protein delivery from polymeric matrices:From pre-formulation stabilization studies to site-specific delivery

https://pure.rug.nl/ws/files/55524889/Propositions.pdf

Protein delivery from polymeric matrices:From pre-formulation stabilization studies to site-specific delivery

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