In spite of vast advances in healthcare services, treatment of snakebite still remains a challenge to medical fraternity, because of unresolved complications of severe local tissue damage and consequential physical disabilities. Though anti-venom therapy reduces mortality, is ineffective against local tissue damage. In vitro and in vivo studies demonstrated that several alkaloids, flavonoids, polyphenols, terpenoids, saponins, sterols, glycosides, etc., from herbal medicines effectively neutralized local tissue damage induced by venom toxins/enzymes. This review emphasizes the interplay of venom toxins/enzymes in local toxicity and their neutralization using phytochemicals. Further, approaches using phytochemicals and anti-venoms are reviewed for better management of snakebite
