Fixed points and limit cycles in the population dynamics of lysogenic viruses and their hosts

Abstract

Starting with stochastic rate equations for the fundamental interactions between microbes and their viruses, we derive a mean field theory for the population dynamics of microbe-virus systems, including the effects of lysogeny. In the absence of lysogeny, our model is a generalization of that proposed phenomenologically by Weitz and Dushoff. In the presence of lysogeny, we analyze the possible states of the system, identifying a novel limit cycle, which we interpret physically. To test the robustness of our mean field calculations to demographic fluctuations, we have compared our results with stochastic simulations using the Gillespie algorithm. Finally, we estimate the range of parameters that delineate the various steady states of our model.Comment: 20 pages, 16 figures, 4 table