Very often, critical quantities related to safety, product quality and economic performance of a chemical process cannot be measured on line. In an attempt to overcome the challenges caused by inadequate on-line measurements, state estimation provides an alternative approach to reconstruct the unmeasured state variables by utilizing available on-line measurements and a process model. Chemical processes usually possess strong nonlinearities, and involve different types of measurements. It remains a challenging task to incorporate multiple measurements with different sampling rates and different measurement delays into a unified estimation algorithmic framework. This dissertation seeks to present developments in the field of state estimation by providing the theoretical advances in multi-rate multi-delay observer design. A delay-free multi-rate observer is first designed in linear systems under asynchronous sampling. Sufficient and explicit conditions in terms of maximum sampling period are derived to guarantee exponential stability of the observer, using Lyapunov’s second method. A dead time compensation approach is developed to compensate for the effect of measurement delay. Based on the multi-rate formulation, optimal multi-rate observer design is studied in two classes of linear systems where optimal gain selection is performed by formulating and solving an optimization problem. Then a multi-rate observer is developed in nonlinear systems with asynchronous sampling. The input-to-output stability is established for the estimation errors with respect to measurement errors using the Karafyllis-Jiang vector small-gain theorem. Measurement delay is also accounted for in the observer design using dead time compensation. Both the multi-rate designs in linear and nonlinear systems provide robustness with respect to perturbations in the sampling schedule. Multi-rate multi-delay observer is shown to be effective for process monitoring in polymerization reactors. A series of three polycondensation reactors and an industrial gas-phase polyethylene reactor are used to evaluate the observer performance. Reliable on-line estimates are obtained from the multi-rate multi-delay observer through simulation
