Thiadiazoles are an important class of heterocyclic compounds that exhibit diverse applications in organic synthesis, pharmaceutical and biological applications. They also known to useful as oxidation inhibitors, cyanine dyes, metal chelating agents, anti-corrosion agents. Attracted by their broad spectrum of applications; researchers across the globe are working on this moiety and consequently have been instrumental in the advancement of thiadiazole chemistry. This review article provides up to date information about developments, exploration of new methods, synthetic strategies, techniques adopted for the synthesis of thiadiazoles and their diverse pharmaceutical activities, structure-activity relationship of the most potent compounds and physical properties. This article can act as an important tool for organic and medicinal chemists to develop newer compounds possessing thiadiazole moiety that could be better agents in terms of efficacy and safety
