Synthesis of isoxazoles via 1,3-dipolar cycloaddition reactions and their antimicrobial activity

Abstract

The ethyl acetoacetate reacts with the nitrile imines generated in situ by the catalytic dehydrogenation of diphenyl hydrazones using chloramine-T (CAT) to afford regioselective cycloadducts in 80% yields respectively. The structures of these compounds have been characterized by FT-IR, (1)H NMR, (13)C NMR and mass spectroscopic techniques and elemental analysis. All the pyrazole derivatives have been tested for their antibacterial and antifungal activities

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