Barkhori, Asma

Simorgh Research Repository

          داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ ﻛﺮﻣﺎن  داﻧﺸﻜﺪه ﭘﺰﺷﻜﻲ  ﭘﺎﻳﺎن ﻧﺎﻣﻪ دوره ﭘﺰﺷﻜﻲ ﻋﻤﻮﻣﻲ   ﻋﻨﻮان:ﻣﻘﺎﻳﺴﻪ ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در ﺑﻴﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﻣﻌﺘﺎد و اﻓﺮاد ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم  ﻣﺘﺎﺑﻮﻟﻴﻚ ﻏﻴﺮ ﻣﻌﺘﺎد  اﺳﺘﺎد راﻫﻨﻤﺎ:  ﺳﺮﻛﺎر ﺧﺎﻧﻢ دﻛﺘﺮ ﻣﻌﺼﻮﻣﻪ ﻛﻬﻨﻮﺟﻲ  ﺗﻮﺳﻂ:  دﻛﺘﺮ اﺳﻤﺎ ﺑﺮﺧﻮري   8931ﻣﺮداد       اﻳﻦ ﭘﮋوﻫﺶ ﺑﺎ ﻫﺪف ﺗﻌﻴﻴﻦ ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در ﺑﻴﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﻣﻌﺘﺎد و  زﻣﻴﻨﻪ و ﻫﺪف:    اﻧﺠﺎم ﺷﺪ. اﻓﺮاد ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﻏﻴﺮ ﻣﻌﺘﺎدﺑﻮد ﻛﻪ ﺑﺎ اﺳﺘﻔﺎده از روش ﻧﻤﻮﻧﻪ  lanoitceS - ssorC اﻳﻦ ﭘﮋوﻫﺶ ﻳﻚ ﻣﻄﺎﻟﻌﻪ از ﻧﻮع  ﻣﻮاد و روش ﻫﺎ:ﺑﻴﻤﺎر ﻏﻴﺮ ﻣﻌﺘﺎد(  05ﺑﻴﻤﺎر ﻣﻌﺘﺎد و  05ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ )ﺷﺎﻣﻞ  001ﮔﻴﺮي ﺗﺼﺎدﻓﻲ آﺳﺎن ﺑﺮ روي ﺑﻴﻤﺎر ﻏﻴﺮ ﻣﻌﺘﺎد( در ﺷﻬﺮﻛﺮﻣﺎن  05ﺑﻴﻤﺎر ﻣﻌﺘﺎد و  05ﻣﻞ ﺑﻴﻤﺎر ﻧﺮﻣﺎل )ﻏﻴﺮ ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﺷﺎ 001و )رﻳﺴﻚ ﻓﺎﻛﺘﻮرﻫﺎي  RDAKREKﻧﻤﻮﻧﻪ ﻫﺎي ﻣﻮرد اﺳﺘﻔﺎده در اﻳﻦ ﻣﻄﺎﻟﻌﻪ از ﻓﺎز دوم ﻣﻄﺎﻟﻌﻪ ي اﻧﺠﺎم ﮔﺮﻓﺖ. . در اداﻣﻪ ﺗﻮﺳﻂ ﭘﮋوﻫﺸﮕﺮ در ﭼﻚ ﻟﻴﺴﺖ ﺟﻤﻊ آوري، ﺑﻪ دﺳﺖ آﻣﺪ ﺑﻴﻤﺎري ﻫﺎي ﺷﺮﻳﺎن ﻛﺮوﻧﺮي در ﻛﺮﻣﺎن(ﺮ ﻫﺎ ﺛﺒﺖ ﮔﺮدﻳﺪ و در ﻧﻬﺎﻳﺖ ﺗﻤﺎﻣﻲ اﻃﻼﻋﺎت ﺟﻬﺖ ﺗﺠﺰﻳﻪ و ﺗﺤﻠﻴﻞ آﻣﺎري وارد ﻧﺮم اﻓﺰار اﻃﻼﻋﺎت ﻣﺮﺑﻮط ﺑﻪ ﻣﺘﻐﻴﻴ  ﮔﺮدﻳﺪ. SSPSﻧﺎﻧﻮﮔﺮم در ﻣﻴﻠﻲ ﻟﻴﺘﺮ ﺑﻮد. ﻧﺘﺎﻳﺞ  043/77 ± 12/6ﻣﻴﺎﻧﮕﻴﻦ ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در ﻛﻞ اﻓﺮاد ﺑﺮاﺑﺮ ﺑﺎ ﻳﺎﻓﺘﻪ ﻫﺎ: ﻧﺸﺎن داد ﻛﻪ ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در اﻓﺮاد ﻣﻌﺘﺎد ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﺑﻪ ﻃﻮر ﻣﻌﻨﺎدار از اﻓﺮاد ﻏﻴﺮ ﻣﻌﺘﺎد ﻛﻤﺘﺮ (. ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در اﻓﺮاد ﻣﻌﺘﺎد ﻏﻴﺮ ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﺑﻪ ﻃﻮر ﻣﻌﻨﺎدار از اﻓﺮاد 871.0=Pﻣﻲ ﺑﺎﺷﺪ )(. ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در اﻓﺮاد ﻣﻌﺘﺎد ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﺑﻪ ﻃﻮر 7320.0=Pﻛﻤﺘﺮ ﻣﻲ ﺑﺎﺷﺪ )ﻏﻴﺮ ﻣﻌﺘﺎد (. ﻫﻤﭽﻨﻴﻦ ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در اﻓﺮاد ﻏﻴﺮ ﻣﻌﺘﺎد 8740.0=Pﻣﻌﻨﺎدار ﺑﺎﻻﺗﺮ از اﻓﺮاد ﻏﻴﺮ ﻣﺘﺎﺑﻮﻟﻴﻚ ﻣﻲ ﺑﺎﺷﺪ )(. ﻫﻤﭽﻨﻴﻦ ﻣﻴﺎن 7530.0=Pﺎﺷﺪ )ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ ﺑﻪ ﻃﻮر ﻣﻌﻨﺎدار ﺑﺎﻻﺗﺮ از اﻓﺮاد ﻏﻴﺮ ﻣﺘﺎﺑﻮﻟﻴﻚ ﻣﻲ ﺑ  ارﺗﺒﺎط آﻣﺎري ﻣﻌﻨﺎداري وﺟﻮد ﻧﺪاﺷﺖ. IMBﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ در اﻓﺮاد ﺷﺮﻛﺖ ﻛﻨﻨﺪه ﺑﺎ ﺳﻦ، ﺟﻨﺲ و ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﻣﺤﺪود ﺑﻮدن ﺣﺠﻢ ﻧﻤﻮﻧﻪ و ﺑﺎزه ي زﻣﺎﻧﻲ ﭘﮋوﻫﺶ ﺑﺮرﺳﻲ ﻫﺎي ﺗﻜﻤﻴﻠﻲ ﺟﻬﺖ ﺗﻌﻴﻴﻦ  ﮔﻴﺮي: ﻧﺘﻴﺠﻪو ﻋﺮوﻗﻲ در ﺑﻴﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ در اﻓﺮاد ارﺗﺒﺎط ﺑﻴﻦ ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ ﺑﻪ ﻋﻨﻮان ﻳﻚ ﻓﺎﻛﺘﻮر ﻗﻠﺒﻲ   ﻣﻌﺘﺎد ﺿﺮوري ﺑﻪ ﻧﻈﺮ ﻣﻲ رﺳﺪ. ﺳﻄﺢ ﺳﺮﻣﻲ آﭘﻠﻴﻦ، ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﻴﻚ، ﻣﻌﺘﺎد ﻛﻠﻴﺪواژه: Abstract Background: The aim of this study was to determine the serum level of apelin in addicted and non-addicted patients with metabolic syndrome. Materials and Methods: This cross-sectional study was performed on 100 patients with metabolic syndrome (including 50 addicted and 50 non-addicted patients) and 100 normal (with out metabolic syndrome) including 50 addicted and 50 non-addicted patients. The samples used in this study were obtained from the second phase of the KERKADR study. The data were recorded by the researcher in the checklist, and the variables were recorded. Finally, all the data were entered into SPSS software for statistical analysis. Results: The mean serum apelin level in all participants was 340.77 ± 13.6 ng / ml. The results showed that serum apelin level was significantly lower in addicts with metabolic syndrome in compromised with non-addicted patients (P= 0.178). Serum apelin levels in addicted without metabolic syndrome were significantly lower in compromised with non-addicted patients (P= 0.0237). Serum apelin levels in addicted patients with metabolic syndrome are significantly higher than non-metabolic particepants (P= 0.0478). Serum apelin levels in non-addicted patients with metabolic syndrome were significantly higher than non-metabolic subjects (P= 0.0357). Also, there was no significant relationship between serum apelin levels and age, gender and BMI. Conclusion: Due to limited sample size and time interval, supplemental studies seems to be necessary to determine the relationship between serum apelin levels as a cardiovascular factor in patients with metabolic syndrome seems to be necessary in addicted patients. Keywords: Apelin Serum Level, Metabolic Syndrome, Addiction.   

مقایسه سطح سرمی آپلین در بیماران مبتلا به سندرم متابولیک معتاد و افراد مبتلا به سندرم متابولیک غیر معتاد

http://eprints.kmu.ac.ir/31416/1/7232.pdf

مقایسه سطح سرمی آپلین در بیماران مبتلا به سندرم متابولیک معتاد و افراد مبتلا به سندرم متابولیک غیر معتاد

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