Heers, C.

Peters, Thies

Pierce, G.N.

Scheufler, E.

Wilffert, B.

The effect of R 56865 (N-[1-[4-(4-fluorophenoxy) butyl]-piperidinyl]-N-methyl-2-benzothiazolamine, CAS 104606-13-5) on Na+/H+exchange and Na+/Ca2+exchange was studied in isolated cardiac sarcolemmal vesicles. R 56865 inhibited Na+/H+exchange with an ED50of 180 μmol/l at a concentration of 0.05 mmol/l Na+. The potency of R 56865 decreased with increasing concentrations of Na+. Na+/Ca2+exchange was also inhibited. The ED50amounted to 45 μmol/l. This ED50was close to that of the reference compound dichlorobenzamil (ED50= 27 μmol/l). The inhibitory potency of R 56865 on Na+/H+and Na+/Ca2+exchange is far too low to explain the already reported beneficial effects of this inhibitor of Na+and Ca+overload during ouabain intoxication and ischemia and reperfusion

ARTS repository - University of Groningen

Interference of N-(1-[4-(4-fluophenoxy)butyl]-piperidinyl)-N-methyl-2-benzothiazolamin e with Na+/H+exchange and Na+/Ca2+exchange in purified cardiac sarcolemmal membranes

Interference of N-(1-[4-(4-fluophenoxy)butyl]-piperidinyl)-N-methyl-2-benzothiazolamin e with Na+/H+exchange and Na+/Ca2+exchange in purified cardiac sarcolemmal membranes

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