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Acute nonbacterial gastroenteritis in hospitalized children: A cross sectional study
Authors
S.G. Darestani
H.R. Monavari
+4 more
A.V. Motlagh
S.J. Nia
S. Noorbakhsh
M.R. Shokrollahi
Publication date
1 January 2014
Publisher
Kowsar Medical Publishing Company
Abstract
Background: Viral acute gastroenteritis (AGE) is a major cause of morbidity in childhood and leads to hospitalization in developed countries, such as Iran. Objectives: The aim of this study was to determine the prevalence and viral types (rotavirus, adenovirus, human parechoviruses-1, and human bocavirus) of acute nonbacterial gastroenteritis in hospitalized children. Patients and Materials: This was a across-sectional prospective study performed at the Pediatric Department of Rasoul Hospital, Tehran, Iran (2009-2011) on 80 hospitalized children with viral AGE. All Stool samples were collected on viral transport media. Human bocavirus (HBoV) was detected using the Real-time PCR TaqMan method. Molecular detection of human parechovirus type 1 (HPeV-1) RNA in stool samples was done using a specific nested reverse transcription PCR (RT-PCR). Rota and adeno virus antigens were sought by rapid chromatographic tests. P values less than 0.05 were considered statistically significant. Results: Fever was determined in 47.5 of cases (38), nausea and vomiting in 42.5 (34), respiratory symptoms in 16.3 (13), abdominal pain in 76. Duration of diarrhea was 1-30 days (mean = 6.3 + 4.3 days). No dehydration was observed in 43.5 of subjects, mild dehydration in 33.8, moderate dehydration in 17.5 and severe dehydration in 5 of cases. Positive rotavirus was found in 48.8 of cases (39), adenovirus in 20 (16), HBoV in 8 (6) and HPeV-1 in 23.2 (19), and adeno and rotaviruses co-infection in 6 (4). The frequency of positive HBoV was significantly lower than adeno and rotaviruses infection (P value = 0.0001). Rotavirus was more frequent in males (P value = 0.003) and in young children (17.49 months vs. 21.44 months) P value = 0.03, CI = -13.4, 5.5. Rotavirus infection was related to the degree of dehydration (P value = 0.001) but was not related to the presence of vomiting or fever (P value > 0.5). Conclusions: This study indicates that viral agents, especially rotavirus (48.8%), HPeV-1 (23.2%) and adenovirus (20%) are the most important causes for viral AGE in children while HBoV (8%) is infrequent during childhood. Determination of various viral pathogens of AGE is very important in planning diarrhea disease control strategies in our country where rotavirus vaccination in not routinely used. © 2014, Ahvaz Jundishapur University of Medical Sciences
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Last time updated on 17/10/2019