The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of sepsis and sepsis-induced organ dysfunction. Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8- tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8- tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof

Bouma, Hjalmar Roland

Henning, Robert Henk

Krenning, Guido

van der Graaf, Adrianus Cornelis

English

Dissertations of the University of Groningen

   University of GroningenChromanol, quinone or hydroquinone compounds for treatment of sepsisBouma, Hjalmar Roland; Krenning, Guido; Henning, Robert Henk; van der Graaf, AdrianusCornelisIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2021Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Bouma, H. R., Krenning, G., Henning, R. H., & van der Graaf, A. C. (2021). Chromanol, quinone orhydroquinone compounds for treatment of sepsis. (Patent No. WO2021246868).CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 21-01-2023

Chromanol, quinone or hydroquinone compounds for treatment of sepsis

Proceedings - University of Groningen

   University of GroningenChromanol, quinone or hydroquinone compounds for treatment of sepsisBouma, Hjalmar Roland; Krenning, Guido; Henning, Robert Henk; van der Graaf, AdrianusCornelisIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2021Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Bouma, H. R., Krenning, G., Henning, R. H., & van der Graaf, A. C. (2021). Chromanol, quinone orhydroquinone compounds for treatment of sepsis. (Patent No. WO2021246868).CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 29-10-2022

   University of GroningenChromanol, quinone or hydroquinone compounds for treatment of sepsisBouma, Hjalmar Roland; Krenning, Guido; Henning, Robert Henk; van der Graaf, AdrianusCornelisIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2021Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Bouma, H. R., Krenning, G., Henning, R. H., & van der Graaf, A. C. (2021). Chromanol, quinone orhydroquinone compounds for treatment of sepsis. (Patent No. WO2021246868).CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 11-09-2023

University of Groningen

   University of GroningenChromanol, quinone or hydroquinone compounds for treatment of sepsisBouma, Hjalmar Roland; Krenning, Guido; Henning, Robert Henk; van der Graaf, AdrianusCornelisIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2021Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Bouma, H. R., Krenning, G., Henning, R. H., & van der Graaf, A. C. (2021). Chromanol, quinone orhydroquinone compounds for treatment of sepsis. (Patent No. WO2021246868).CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 20-11-2022

ARTS repository - University of Groningen

   University of GroningenChromanol, quinone or hydroquinone compounds for treatment of sepsisBouma, Hjalmar Roland; Krenning, Guido; Henning, Robert Henk; van der Graaf, AdrianusCornelisIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2021Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Bouma, H. R., Krenning, G., Henning, R. H., & van der Graaf, A. C. (2021). Chromanol, quinone orhydroquinone compounds for treatment of sepsis. (Patent No. WO2021246868).CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 07-06-2022

   University of GroningenChromanol, quinone or hydroquinone compounds for treatment of sepsisBouma, Hjalmar Roland; Krenning, Guido; Henning, Robert Henk; van der Graaf, AdrianusCornelisIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2021Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Bouma, H. R., Krenning, G., Henning, R. H., & van der Graaf, A. C. (2021). Chromanol, quinone orhydroquinone compounds for treatment of sepsis. (Patent No. WO2021246868).CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 05-12-2023

https://pure.rug.nl/ws/files/209742856/WO2021246868_A1.pdf

Chromanol, quinone or hydroquinone compounds for treatment of sepsis

Abstract

Similar works

Full text

Available Versions

Dissertations of the University of Groningen

Proceedings - University of Groningen

Proceedings - University of Groningen

University of Groningen

ARTS repository - University of Groningen

Dissertations of the University of Groningen

ARTS repository - University of Groningen