Novychenko, S.D.

Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету

388Muzyka N.Y.EXPERIMENTAL STUDY OF PHARMOCOLOGICAL PROPERTIES OF A NEWHERBAL PREPARATION OF ALTABOR SUPPOSITORIESDepartment of PharmacyBukovynian State Medical UniversityNowadays, prostate diseases, in particular, chronic prostatitis is considered to be one ofthe acute medical and social problems. It prevails among urological diseases and causesinfertility, impotence. According to recent studies, approximately 30-45% of men suffer fromchronic prostatitis. In other words, almost every third middle-aged man in Ukraine is diagnosedwith inflammation of the prostate. This problem is extremely serious as there is the tendency ofthe number of patients with chronic prostatitis to increase, which, in turn, takes place due to thedecrease in the immunoresistance of a body and increased exposure to adverse environmentalconditions.Pharmacocorrection is etiopathogenetic in nature and involves the use of drugs ofdifferent pharmacological groups (antibacterial, muscle relaxants, antispasmodics, 5-α-reductaseinhibitors, α-blockers, herbal drugs, etc.) The leading mechanisms of prostate pathology are notprecisely established. That is why the effectiveness of many drugs has not been confirmed interms of evidence-based medicine. Prostate protectors are especially highlighted in the list ofdrugs used to treat prostatopathy. These drugs have a cytoprotective effect, inhibit the process ofexcessive peroxidation, improve microcirculation in prostate tissues, provide high resistance tothe development of inflammatory reactions, hyper- and neoplasia in the prostate etc.The choice of domestic prostate protectors is rather limited in Ukraine. That is whypeople use imported drugs for the treatment of prostatitis. Unfortunately, this type of treatmentremains unaffordable for many people. As a consequence, the development and implementationof effective and safe domestic drugs are absolutely essential for the treatment and prevention ofprostatitis.Novychenko S.D.CHARACTERISTICS OF HYPERTENSION IN PATIENTS WITH DIABETICNEPHROPATHYDepartment of PharmacologyBukovinian State Medical UniversityHemodynamic disturbances, occurring early or late as response to any pathologicalprocesses in the kidneys, are of great significance nowadays in the development of progressivenessof chronic kidneys disease (CKD). Dystrophic and scleral pathological processes that have more orless pronounced diffuse character, considered to acquire steady progression just due to stablehemodynamic changes. Kidney Doppler ultrasonography as relatively new ultrasound method ofinvestigation of the organ bloodcirculation, occupied deserving place in cardiology, obstetrics andgynecology, vascular surgery and transplantology.The aim of this abstract was to make better diagnostics and dynamic control of the quality oftreatment of patients suffering from chronic kidney disease with arterial hypertension presence bymeans of color duplex Doppler ultrasonography investigation of the renal organ blood flow. Thestudy involved 55 men (41.98%) and 76 women (58.02%) aged 29-65 years (mean age 46.50±2.25years) with the 5-10 year history of CKD and hypertension.All patients underwent Dopplerultrasound renal scanning to evaluate morphological changes of kidney structure and patterns of therenal vascularization. Investigation was carried out in the triplex regimen (B-mode ultrasound,colour duplex scanning, mapping, and spectral analysis of Doppler shift frequency) withmeasurement of the peak systolic velocity (Vs), end-diastolic velocity (Vd), time-averagedmaximum blood flow rate (TAMX) in а.interlobaris, and calculation of the volume velocity (Vvol)and renal resistive index (RRI = (Vs–Vd)/Vs). All values were calculated automatically.Some patients (from 69 ) with AH during this period of time received lisinopril at a dose of10 mg and amlodipine at a dose of 5 mg (39 patients) with the object to normalize AP and the389remaining 35 patients received monotherapy with lisinopril 10 mg 1- 2 times a day (individuallyselected doses) and, if necessary, diuretics .During  one-year follow-up,  the stage of CKD changedto CKD stage III in 11 patients from the group under observation.The treatment of nephrologicalpathology carried out in accordance with the existing principles of therapy of the detectednephrological diseases. Тhe indices of the renal blood flow against a background of 6-monthtreatment with the use of antihypertensive pathogenetic therapy combination of lisinopril andamlodipine, veritably decreased in many cases at the level of a. segmentalis. In patients with CP, allindices did not differ from normal values of almost healthy individuals (p <0.05), except index Vd.In patients with CKD, Vd (p <0.05) and IR (p <0.05) values probably decreased but did not differfrom the normal values. And in DN group of patients with hypertension, the indices were torpedoand did not respond to 6-month therapy of the combined use of lisinopril at a dose of 10 mg andamlodipine at a dose of 5 mg once a day. Patients,who were taking lisinopril as monotherapy forrenal hypertension, did not show significant changes in the renal blood flow during the 6-monthtreatment period (p> 0.05).Thouse, it has been determined that the combined use of lisinopril at a dose of 10 mg andamlodipine at a dose of 5 mg per day in the complex therapy of CKD stage I-II patients with AHstage II during a year contributes to the probable improvement of the renal blood flow indices (Vs,Vd, Vvol, TAMX, IR) (p <0.05) of the small renal vessels (at the level of a.interlobaris).Pazyniuk A.Yu.FEATURES OF PHARMACEUTICAL EDUCATION ABROADDepartment of PharmacyBukovinian State Medical UniversityOver the past two decades, the pharmaceutical market has grown significantly, and revenuesfrom drugs worldwide in 2020 amounted to 1.27 trillion US dollars. The United States has becomethe world's leading pharmaceutical market. European countries (Germany, France, Great Britain)are not the last in their contribution to the pharmaceutical industry. The results of thepharmaceutical organization largely depend on the qualifications and educational level of staff.After all, only high-quality education contributes to personal and professional development, as wellas social, cultural, economic, political and environmental development of the country as a whole.The purpose of the study was the analysis of educational programs for students of leadingforeign universities in the field of pharmacy.The results of the analysis were obtained after exploring the educational programs of thefollowing universities: University of Bonn (Federal Republic of Germany), University of Nantes(France), University of Birmingham (United Kingdom), University of Florida (United States ofAmerica), Niigata University of Pharmacy and Applied Life Sciences (Japan).Curricula of European universities (Federal Republic of Germany, France, Great Britain)have minimal differences from the education of pharmaceutical students in Ukraine.Upon graduation from French universities, students, in addition to a diploma of highereducation, receive a certificate confirming the level of English language proficiency.The 4-year education in the UK is the shortest of the European pharmaceutical degrees. Theinternship at the University of Great Britain begins at the end of the first year of study. Aftergraduation, a year-long internship outside the university on public and industrial pharmacy ismandatory, after which there is an exam in the Royal Pharmaceutical Society to confirmprofessional qualifications. An interesting fact is the lack of refresher courses for pharmaceuticalworkers in the UK because every pharmacist must adhere to the Standards of ContinuingProfessional Development made by the General Pharmaceutical Council. Perhaps this helps toincrease the self-awareness of pharmaceutical workers in terms of self-education.There aren't any possible ways to enter one of the higher educational complexes in the USAimmediately after graduation from school. Firstly, a student must complete a 2-3 year pre-pharmacyor pre-professional preparatory course, which serves as a preparatory cycle of education. You canattend them in any regional accredited technical (Technical), municipal (Community Colleges) or

Characteristics of hypertension in the patients with diabetic nephropathy

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Characteristics of hypertension in the patients with diabetic nephropathy

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Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету