Bansi, Jens

Gonzenbach, Roman

Proschinger, Sebastian

Weise, Andrea

English

ZHAW digitalcollection

High-Intensity Interval Training affects physical components of Quality of Life and Skills in Daily Activities in Multiple Sclerosis – Interim analysis of a Randomized Controlled TrialSebastian Proschinger2, Annette Rademacher2, Niklas Joisten2, Alexander Schenk2, Max Oberste2, Roman Gonzenbach1, Jan Kool1, Andrea Weise1, Philipp Zimmer2 and Jens Bansi11 Rehabilitation Centre Valens, 7317 Valens, Switzerland2  Deutsche Sporthochschule, Köln, Deutschland       INTRODUCTION Persons with multiple sclerosis (pwMS) progressively develop impaired functioning that directly impacts health related quality of life (HRQoL) and performance skills in every day life. Physical activity reveals high potential as a non-pharmacological treatment to beneficially impact both motor and process performance. The relevance of regular moderate to high-intensive interval (HIIT) exercise for ameliorating psychomotor symptoms in pwMS is becoming more evident.METHODS Randomized controlled clinical trial in n=77 pwMS. In this interim analysis n=58 participants are analyzed. The HIIT group (n=30) cycled at 95–100% of HRmax (80–100 rpm) during 5× 1.5-min high-intensive intervals with 2 min of unloaded cycling in between, whereas CT (n=28) cycled continuously for 24 minutes at 65% of HRmax (60–70 rpm). Performance skills in daily activities were assessed with the Assessment of Motor and Process Skills (AMPS),  HRQoL was assessed using the patient-reported outcome measurement information system (PROMIS) short form Global-10.  All assessments were performed at the beginning (T0) and end of a three week training intervention (T3). Effects of between-subject and within-subject factor measurement time-points (baseline vs. post intervention) have been analyzed by ANCOVA. RESULTSNo significant group interaction for either outcome measure was observed. However, physical HRQoL improved significantly only in the HIIT group (p=.0001). Mental HRQoL improved significantly in both groups (HIIT: p=.017; control: p=.001). While there is a significant improvement of motor performance in daily activities only in the HIIT group (p=.025), no changes are observed in the process performance in either group. OBJECTIVESTo determine the influence of high-intensity interval training (HIIT) vs. moderate training (CT) over three weeks on HRQoL and motor & process skills in daily activities of pwMS with a moderate disability status (EDSS: 4.0-6.0)CONCLUSIONSHIIT had stronger impact on physical characteristics of HRQoL and performance skills than moderate training (CT) in pwMS. This is shown by significant improvements of better Global Physical Health (PROMIS) and better motor performance (AMPS).

High-intensity interval training affects physical components of quality of life and skills in daily activities in multiple sclerosis : interim analysis of a randomized controlled trial

https://digitalcollection.zhaw.ch/bitstream/11475/19340/3/SOTA20_JB_15012020_V5_final-1.pdf

High-intensity interval training affects physical components of quality of life and skills in daily activities in multiple sclerosis : interim analysis of a randomized controlled trial

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