Development of sustained release formulation of glipizide using natural polymer from Tamrindus indica for better patient compliance

Abstract

The study was to design a drug product to reduce the frequency of dosing, increase therapeutic effectiveness and improvement in patient compliance, by developing sustained release matrix tablet of Glimepiride using tamrind gum as a release modifier. In current study tamrind gum is used as a polymer which is investigated for sustained release carrier. The pre-formulation studies of drug excipient mixtures were performed. The tablets formulated were evaluated by physicochemical studies, in- vitro drug release, kinetic studies and stability studies. Drug and polymers has no interaction as observed by FTIR and UV studies. All the physicochemical parameters of tablets were found in the limits. Glimepiride is used in the treatment type II diabetes mellitus and is a first third generation sulphonyl urea agent. The drug release pattern was studied for extended period of 12 hrs for the optimized formulations. The release of drug under kinetic studies showed that it follows first order models. The different tablet formulations were put to stability studies and it was observed that there were no significant changes in release pattern, physicochemical parameters and drug content. The present study result indicates the suitability of the tamrind gum polymer in the preparation of sustained release formulations of glimepiride. Keywords: Sustained Release, Glipizide , Natural Polymer, Tamrindus Indic