Background: Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages

AH Jobe

ALN Alvarenga

B Walter

Barbara E. Lingwood

DR Miller

EL Swart

Eugenie R. Lumbers

G Hasenfuss

G Schmid

GC Liggins

GP Aylward

Helen L. Keates

J Dobbing

J Estrada

JH Burrell

JJ Coalson

JL Morrison

JMD Thompson

JP Newnham

JS Quaedackers

JW Logan

KM Stevenson

Layne L. Wright

M Laughon

MA Thomson

Martin Gerbert Frasch

ME Probyn

MJ Johnson

NP French

P Sengupta

Paul B. Colditz

PT Sangild

R Bauer

R De Matteo

SF Wu

SL Miller

SM Williams

ST Bjorkman

Stella T. Bjorkman

Stephanie M. Miller

Viskasari P. Kalanjati

WG Pond

Yvonne A. Eiby

PubMed

BACKGROUND: Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages. METHODS: Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols. RESULTS: Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability. CONCLUSION: The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes

Yvonne A Eiby

Layne L Wright

Viskasari P Kalanjati

Stephanie M Miller

Stella T Bjorkman

Helen L Keates

Eugenie R Lumbers

Paul B Colditz

Barbara E Lingwood

Directory of Open Access Journals

PLoS ONE

A pig model of the preterm neonate: anthropometric and physiological characteristics.

Eiby, Yvonne A.

Wright, Layne L.

Kalanjati, Viskasari P.

Miller, Stephanie M.

Bjorkman, Stella T.

Keates, Helen L.

Lumbers, Eugenie R.

Colditz, Paul B.

Lingwood, Barbara E.

University of Queensland eSpace

A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics

Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages.Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols.Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability.The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes

Eiby Yvonne A.

Wright Layne L.

Kalanjati Viskasari P.

Miller Stephanie M.

Bjorkman Stella T.

Keates Helen L.

Lumbers Eugenie R.

Colditz Paul B.

Lingwood Barbara E.

Public Library of Science (PLOS)

Background



Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages.

Methods



Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols.

Results



Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability.

Conclusion



The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes

Eiby, Yvonne A

Kalanjati, Viscasari P.

Miller, Stella M.

Universitas Airlangga Repository

English

A Pig Model of the Preterm Neonate: Anthropometric

and Physiological Characteristics

Crossref

Background: Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages. Methods: Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term=115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols. Results: Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability. Conclusion: The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes

CiteSeerX

Background: Large animal models are an essential tool in the development of rationally-based new clinical therapies for preterm infants. We provide a description of the newborn pig as a model of the preterm neonate in terms of growth parameters, physiology and the requirement for intensive care over a range of gestational ages. Methods: Twenty-nine litters of piglets (n = 298) were delivered by caesarean section at six timepoints during gestation from 91d to 113d (term = 115d). Two groups, at 91 and 97d gestation, also received maternal glucocorticoid treatment. At four of these timepoints, piglets (n = 79) were ventilated, sedated and monitored using standard neonatal intensive care techniques for up to 8 h in various experimental protocols. Results: Body weight increased from mean 697 g (SD 193) at 91d gestation to 1331 g (SD 368) at 113d gestation. Piglets delivered at 97d gestation were able to be resuscitated and kept alive for at least 8 h on respiratory support after surfactant administration. Maternal glucocorticoid treatment 48 h and 24 h hours prior to delivery reduced the requirement for ventilator support and improved cardiovascular stability. Conclusion: The pig provides a relevant model for the study of human preterm physiology and for investigation of novel therapies to improve outcomes

University of Newcastle's Digital Repository

A pig model of the preterm neonate: anthropometric and physiological characteristics

file:///data/core-remote/dit/data/public_library_of_science/pdf/a59/ZnRwOi8vZnRwLm5jYmkubmxtLm5paC5nb3YvcHViL3BtYy9vYV9wYWNrYWdlLzNiLzFiL1BNQzM3MDYzNjUudGFyLmd6.pdf

A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics

Abstract

Similar works

Full text

Available Versions

Directory of Open Access Journals

University of Queensland eSpace

Public Library of Science (PLOS)

Public Library of Science (PLOS)

Universitas Airlangga Repository

Crossref

CiteSeerX

Universitas Airlangga Repository

University of Newcastle's Digital Repository