Jennings, Rachel

English

VCU Scholars Compass

Virginia Commonwealth University VCU Scholars Compass Biology and Medicine Through Mathematics Conference 2022 May 19th, 9:00 AM - 9:30 AM A Mathematical Model of Innate and Adaptive Immune Responses Initiated by Superficial Burn Injury Rachel Jennings rljennings@ara.com Follow this and additional works at: https://scholarscompass.vcu.edu/bamm  Part of the Life Sciences Commons, Medicine and Health Sciences Commons, and the Physical Sciences and Mathematics Commons https://scholarscompass.vcu.edu/bamm/2022/thur/2 This Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has been accepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. For more information, please contact libcompass@vcu.edu. A Mathematical Model of Innate and Adaptive Immune Responses Initiated by Superficial Burn Injury, Rachel Jennings1, Amy Creel1, Christina Wagner1, and Angela Reynolds2  1Applied Research Associates, Arlington, VA, USA 1Department of Mathematics, Virginia Commonwealth University, Richmond, VA, USA   It is estimated that 1.1 million people in the United States suffer from burn injuries annually. Understanding the collective effects of burns is fundamental for gauging injury severity and predicting healing outcomes. To repair tissue damage, an overlapping, coordinated sequence of events involving highly specialized cells and their byproducts occurs. Pathological inflammation during this process impairs wound healing, increasing the likelihood of adverse health outcomes. Here, we introduce an immunophysiological model of local dermal wound healing following superficial burn injury. The model consists of a system of nonlinear ordinary differential equations that describe dynamics between various innate (neutrophils, macrophages) and adaptive (T lymphocytes) immune cells, as well as early fibroblast activity at the site of injury. A representative parameter set was extracted to establish baseline values. Using the time series predictions for the baseline values as the comparator, numerical simulations were performed, allowing us to further verify the biological plausibility of model’s behaviors.  We then utilize the model to explore the effect of different inflammatory profiles in promoting timely tissue healing and preventing secondary infection for burn injury.    

A Mathematical Model of Innate and Adaptive Immune Responses Initiated by Superficial Burn Injury

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1495&context=bamm

A Mathematical Model of Innate and Adaptive Immune Responses Initiated by Superficial Burn Injury

Abstract

Similar works

Full text

Available Versions

VCU Scholars Compass