Jennings, Rachel

Rose, Morgan

Schroeter, Jeffry

English

VCU Scholars Compass

Virginia Commonwealth University VCU Scholars Compass Biology and Medicine Through Mathematics Conference 2022 May 18th, 5:00 PM - 7:00 PM A Within-Host Modeling Framework For SARS-CoV-2 Infection to Support Vaccine Strategies Morgan Rose Applied Research Associates, Inc., mrose@ara.com Rachel Jennings Applied Research Associates, Inc., rljennings@ara.com Jeffry Schroeter Applied Research Associates, Inc., jschroeter@ara.com Follow this and additional works at: https://scholarscompass.vcu.edu/bamm  Part of the Life Sciences Commons, Medical Immunology Commons, Physical Sciences and Mathematics Commons, and the Virus Diseases Commons https://scholarscompass.vcu.edu/bamm/2022/wed/37 This Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has been accepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. For more information, please contact libcompass@vcu.edu. A Within-Host Modeling Framework For SARS-CoV-2 Infection to Support Vaccine Strategies, Jeffry Schroeter1, Rachel Jennings1, Morgan Rose1, Jonathan Rolfs1, and Angela Reynolds2  1Applied Research Associates, Arlington, VA, USA 1Department of Mathematics, Virginia Commonwealth University, Richmond, VA, USA  COVID-19 initially develops as a respiratory infection but may progress systemically. Vaccines have garnered much attention due to their rapid development in response to the COVID-19 pandemic and their dramatic success in reducing viral spread. Here, we introduce a mathematical model to study mucosal and systemic immunity conferred by intramuscular and intranasal vaccines following exposure to SARS-CoV-2. The model delineates between viral kinetics in the upper and lower respiratory tracts as well the differentiates between the immunological responses activated at each site. Numerical simulations were performed in an effort to assess optimal vaccination strategies, which may include a combination of intranasal and intramuscular vaccines to elicit a sufficient combined mucosal and systemic immune response.  

A Within-Host Modeling Framework For SARS-CoV-2 Infection to Support Vaccine Strategies

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1497&context=bamm

A Within-Host Modeling Framework For SARS-CoV-2 Infection to Support Vaccine Strategies

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