Capaldi, Alex

Cornwell, Eva

Elzinga, David

Stowe, Shelby R

English

VCU Scholars Compass

Virginia Commonwealth University VCU Scholars Compass Biology and Medicine Through Mathematics Conference Modeling vaccination strategies to control white-nose syndrome in little brown bat colonies Eva Cornwell St. Olaf College, cornwe1@stolaf.edu David Elzinga University of Tennessee, Knoxville, delzinga@vols.utk.edu Shelby R. Stowe Colorado School of Mines, sstowe@mymail.mines.edu See next page for additional authors Follow this and additional works at: https://scholarscompass.vcu.edu/bamm  Part of the Dynamical Systems Commons, Immunity Commons, and the Population Biology Commons https://scholarscompass.vcu.edu/bamm/2020/talk/21 This Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has been accepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. For more information, please contact libcompass@vcu.edu. Presenter Information Eva Cornwell, David Elzinga, Shelby R. Stowe, and Alex Capaldi This event is available at VCU Scholars Compass: https://scholarscompass.vcu.edu/bamm/2020/talk/21 Presentation for Biology and Medicine Through Mathematics (BAMM!) 2020 May 2020Modeling vaccination strategies to control white-nosesyndrome in little brown bat coloniesEva Cornwell1, David C. Elzinga2,*, Shelby R. Stowe3, Alex Capaldi41Department of Mathematics, Statistics, and Computer Science, St. Olaf College, Northfield, MN 550572Department of Mathematics, University of Tennessee, Knoxville, TN 379963Department of Mathematics & Statistics, Colorado School of Mines, Golden, CO 804014Department of Mathematics & Statistics, Valparaiso University, Valparaiso, IN 46383* denotes speakerdelzinga@vols.utk.eduSince 2006, the North American bat population has been in rapid decline due to white-nose syndrome(WNS), which is caused by an invasive fungus (Pseudogymnoascus destructans). The little brown bat(Myotis lucifugus) is the species most affected by this emerging disease. We consider how best to preventlocal extinctions of this species using mathematical models. In 2017, development began on a new vaccinefor WNS; we analyze the effects of implementing vaccination as a control measure. We create a Susceptible-Exposed-Infectious-Vaccinated hybrid ordinary differential equation and difference equation model informedby the phenology of little brown bats. We compare the effectiveness of annual, biennial, and one-timevaccination programs for multiple durations of immunity length. We also determine the optimal time tovaccinate, if vaccinating only once, as a function of average duration of immunity. Next, we perform asensitivity analysis to determine the robustness of our results. Finally, we consider other possible controlmeasures together with vaccination to determine the optimal control strategy. We find that if the vaccineoffers lifelong immunity, then it will be the most effective control measure considered thus far.

Modeling vaccination strategies to control white-nose syndrome in little brown bat colonies

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1393&amp;context=bamm

Modeling vaccination strategies to control white-nose syndrome in little brown bat colonies

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