van Duijn, Bert

van Haastert, Peter J. M.

English

Chemotaxis is cell movement in the direction of a chemical and is composed of two components: movement and directionality. The directionality of eukaryotic chemotaxis is probably derived from orientation: the detection of the spacial gradient of chemoattractant over the cell length. Chemotaxis was investigated in eukaryotic Dictyostelium discoideum cells that were permeabilized by high-voltage discharges. These permeable cells respond chemotactically to extracellular cAMP. However, locomotion is impaired if the Ca2+ concentration is clamped at submicromolar concentrations; interestingly, these non-motile cells still form pseudopodia and elongate in the direction of the cAMP gradient. These results imply that locomotion and orientation during Dictyostelium chemotaxis are independently regulated

ARTS repository - University of Groningen

Independent control of locomotion and orientation during Dictyostelium discoideum chemotaxis

https://pure.rug.nl/ws/files/3325574/1992JCellScivDuijn.pdf

Independent control of locomotion and orientation during Dictyostelium discoideum chemotaxis

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ARTS repository - University of Groningen