Visser, Thomas Jakob

English

In this thesis the synthesis and radiolabelling of two potent muscarinic antagonists are described. Both radioligands were shown to be very useful for imaging muscarinic receptors in rats. In a pilot study executed with one of these antagonists in three healthy volunteers, muscarinic receptors in the lungs could be clearly visualized. Now, the way is paved for the determination of receptor densities with compartment models and multiple injection protocols and comparative studies between patients suffering from asthma andlor COPD, and healthyvolunteers

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   University of GroningenDevelopment of new muscarinic and ß-adrenergic receptor radiopharmaceuticals for PositronEmission TomographyVisser, Thomas JakobIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:1997Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Visser, T. J. (1997). Development of new muscarinic and ß-adrenergic receptor radiopharmaceuticals forPositron Emission Tomography: application to lungs, heart and brain. s.n.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 06-06-2022

Development of new muscarinic and ß-adrenergic receptor radiopharmaceuticals for Positron Emission Tomography:application to lungs, heart and brain

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Development of new muscarinic and ß-adrenergic receptor radiopharmaceuticals for Positron Emission Tomography:application to lungs, heart and brain

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