Abdulahad, Wayel Habib

English

Although the pathogenetic mechanisms involved in Wegener’s granulomatosis (WG) are not completely understood, considerable evidence support the concepts that activated T-cells play an important role in disease expression. It is, however, not clear which subsets of T-cells are involved in the aberrant (auto)immune response in WG. Zie: Summar

ARTS repository - University of Groningen

   University of GroningenT-cell mediated immunity in Wegener's granulomatosisAbdulahad, Wayel HabibIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2008Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Abdulahad, W. H. (2008). T-cell mediated immunity in Wegener's granulomatosis. s.n.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 06-06-2022   Studies presented in this thesis were financially supported by:  German Research Foundation (DFG)  Groningen University Institute for Drug Exploration (GUIDE)  Jan Kornelis de Cock Stichting   The printing of this thesis was financially supported by:  Friedrich Wegener Stichting (FWS)  Stichting Werkgroep Interne Reumatologie (SWIR)  Groningen University Institute for Drug Exploration (GUIDE)  University of Groningen   Dutch Arthritis Association BD Biosciences  Roche B.V.  Novartis B.V.  Phadia B.V.            ISBN 978-90-367-3385-4 (printed version)  978-90-367-3386-1 (digital version)  Copyright© 2008  Wayel H. Abdulahad  All rights reserved. No part of this book may be  reproduced or transmitted in any form or by any means,  without the written permission of the author.   Cover design & lay-out          Wayel H. Abdulahad This thesis was printed by    Doorn drukkerij, Groningen, The Netherlands        RIJKSUNIVERSITEIT GRONINGEN    T-cell mediated immunity in Wegener’s granulomatosis    Proefschrift    ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 4 juni 2008 om 13.15 uur    door    Wayel Habib Abdulahad geboren op 19 maart 1969 te Ankawa / Irak       Promotores:   Prof. Dr. C.G.M. Kallenberg   Prof. Dr. P.C. Limburg  Copromotor:   Dr. C.A. Stegeman  Beoordelingscommissie:   Prof. Dr. P.E. de Jong   Prof. Dr. R.J.M. ten Berge   Prof. Dr. A.J.M. van Oosterhout                                    ISBN: 978-90-367-3385-4                                                     Voor mijn ouders       Voor Suha, Mark en Jovan   Paranimfen:   Bert Holvast   Henko Tadema                                              CONTENTS  Chapter 1  Introduction to this thesis.      Chapter 2 CD4-positive effector memory T-cells participate in   disease expression in ANCA-associated vasculitis.  Chapter 3 Persistent expansion of CD4+ effector memory T-     cells in Wegener’s granulomatosis.  Chapter 4 Urinary CD4 effector memory T-cells as a measure of renal disease activity in ANCA-associated vasculitis.  Chapter 5 CD25+CD4+ regulatory T-cells in systemic autoimmune diseases.  Chapter 6 Functional defect of circulating regulatory CD4+T-cells in patients with Wegener’s granulomatosis in remission.  Chapter 7 Skewed distribution of Th17 lymphocytes in patients with Wegener’s granulomatosis in remission.  Chapter 8 Summary, general discussion and future perspectives.   Chapter 9 Summary in Dutch.     Acknowledgments   List of publications       9  17    29    51     67    91     113     133    147   155   159      

T-cell mediated immunity in Wegener's granulomatosis

https://pure.rug.nl/ws/files/2736892/00_titlecon.pdf

T-cell mediated immunity in Wegener's granulomatosis

Abstract

Similar works

Full text

Available Versions

ARTS repository - University of Groningen