anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as
potential anticancer drugs. Herein, we briefly discuss the importance of reactive oxygen species in biological applications and
copper(II) complexes as anticancer drugs. The anti-angiogenic properties of mono-nuclear copper(II) complexes have been
demonstrated by in vivo chick embryo angiogenesis analysis. The plausible mechanism behind anticancer activity of these
complexes is by the formation of excessive intracellular Reactive Oxygen Species (ROS). ROS is a composite term used for
oxygen derivative non-radicals and free radicals of highly reactive components, that enhances the killing response of immune
cells to microbial invasion. Previous reports have shown that ROS plays an important role as a messenger in cell cycling and
normal cell signal transduction