Malignant mesothelioma (MM) is rare and difficult to diagnose. Its identification dependsupon pathological investigation (cyto-histological assessment and immunohistochemistry)supported by clinical and radiological evidence. In the last decade, thestandardization of diagnostic methods has become a major focus of debate among pathologistsand clinicians. This has led to the writing of guidelines and recommendationfor the diagnosis to achieve the goal of a standard diagnosis. In this article, a chronologicalview relating to the pathological diagnosis of MM is presented together with a reviewof guidelines and recommendations.
