The objectives of this study were to measure the concentrations of copper, zinc, cadmium and lead in the tissues of fish species captured from Strait of Bali, Indonesia, to evaluate their mean level in relation to the maximum residual limit for human consumption, to estimate the weekly intake, and to compare it with the provisional tolerable weekly intake (PTWI). The concentrations of copper, zinc, cadmium and lead in all fish ranged from 0.72-2.22, 3.36-13.16, 0.005-0.026, and 1.50-2.48 mg.kg -1 respectively. The level of Pb in all fish exceeds the permissible limit for human consumption, whereas the one of Cu, Zn and Cd did not exceed the permissible limit for human consumption. The estimated weekly intakes of Cu, Zn, and Cd were below the recommended values of PTWI. However, the weekly intake of Pb was higher than the PTWI values