This research aims to collect and classify information on the biology and culture of the prawn Macrobrachium tenellum, in a clear and sequential manner, which would integrate the knowledge to develop new ways in research and sustainable exploitation of this resource. It covers various topics including taxonomy and systematics, geographic distribution, ecology, reproduction, development, pathology, fisheries and aquaculture of this species, taking into account all the information generated by different authors, from four decades to today. We conclude that there are significant knowledge gaps of basic and applied aspects of the biology of the species and this requires a great deal of research for the correct understanding of this native organism to allow for its protection and proper utilization. It is recommended to take special interest in studies to fully know its distribution, the effects of pollution and the loss of its natural habitats. It is necessary to review the regulations for the use and conservation, and to develop and improve aquacultural management techniques
