HELFRICH, W

KEMSHEAD, JT

MALIK, A

PATEL, K

ROSSELL, RJ

A cDNA clone, designated NC7, has been isolated from human foetal kidney that partially codes for the 140 kDa isoform of human NCAM. This clone contains a 6 bp insert that is not present in the human muscle cDNA clone lambda-4.4. This same sequence has also been found in both a cDNA clone obtained from a human Small Cell Lung Carcinoma (SCLC) line and in human genomic DNA. Furthermore, an equivalent sequence to the 6 bp region identified in the above samples is present in mouse, rat and chicken NCAM. The 6 bp insertion does not lie at a predicted intron/exon boundary as extrapolated by homology studies with the chicken and, therefore, the mechanism by which the sequence is deleted from the human muscle clone lambda-4.4 remains unclear.</p

A DISCORDANCE BETWEEN THE HUMAN MUSCLE NCAM SEQUENCE AND THOSE SEEN IN OTHER NCAM CDNA CLONES

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Proceedings - University of Groningen