Prakash, Jai

English

The present thesis is focused on the development of a novel therapeutic system by which anti-fibrotic drugs can be delivered selectively to the kidneys. Renal fibrosis is a final common process of many chronic renal diseases. It is characterized by overdeposition of the extracellular matrix, which eventually leads to the end-stage renal disease (ESRD). Several renal disorders such as diabetic nephropathy, chronic glomerulonephritis, tubulointerstitial fibrosis and hypertensive nephrosclerosis can result into ESRD. The ultimate therapy for ESRD is dialysis or renal transplantation but these treatments have many medical and social disadvantages and are not always successful. The escalating prevalence of ESRD demands therefore for novel therapeutical strategies. Renal selective delivery aims to increase the therapeutic efficacy of drugs by increasing the amount of drugs locally within kidneys. The thesis attempts to provide a general overview of drug targeting approaches by encompassing different linking techniques to couple drug to LZM, different characterization techniques of drug-carrier conjugates, studies on in vitro drug-release and in vivo pharmacokinetic profiles of the conjugates. In addition, the pharmacological evaluation of the conjugates as described in the present study provides further insight in the role of the targeted kinases and profibrotic mediator systems, and thus may contribute to the development of novel therapies for renal fibrosis

Proceedings - University of Groningen

   University of GroningenRenal-specific delivery of antifibrotic drugs using lysozymePrakash, JaiIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2006Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Prakash, J. (2006). Renal-specific delivery of antifibrotic drugs using lysozyme: a novel approach for thetreatment of renal fibrosis. s.n.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 03-06-2022Awards  173 Awards • Received “Ubbo Emmius International Scholarship” for 4 years (since November 1, 2002) from the University of Groningen to pursue Ph.D. in this university.  • Awarded with the Best Poster Presentation Award at an International Symposium on Recent Advances in Pharmacology held on Jan 7-8, 2004 in New Delhi, India. • Awarded with the 2nd Best Poster Presentation Award in “GUIDE early summer meeting 2005” June 17, 2005, Groningen, The Netherlands. • Received a prestigious ISN Travel Grant of 1000 US$ plus free registration fee from the International Society of Nephrology (ISN) to present my work at the 3rd World Congress of Nephrology in Singapore held on June 26-30, 2005.    Appendix 

Renal-specific delivery of antifibrotic drugs using lysozyme:a novel approach for the treatment of renal fibrosis

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Renal-specific delivery of antifibrotic drugs using lysozyme:a novel approach for the treatment of renal fibrosis

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Proceedings - University of Groningen