Poolman, Bert

Slotboom, Dirk-Jan

English

Most ABC importers known to date employ a soluble substrate-binding protein to capture the ligand and donate the molecule to the translocator. The SBP can be a soluble periplasmic protein or tethered to the membrane via a lipid moiety or protein anchor or fused to the translocator. In the hybrid ABC transporters, multiple SBDs can be fused in tandem and provide several extracytoplasmic substrate-binding sites. A subset of ABC transporters employs a membrane-embedded S-component to capture the substrate. The S-component together with the ECF module also forms the translocation path for the substrate. Multiple S-components can associate consecutively with one and the same ECF module. An overview of the mechanism of substrate capture by different types of ABC transporters is presented, together with a scheme illustrating the alternating access mechanism for the overall transport process

Proceedings - University of Groningen

Substrate Capture by ABC Transporters

https://pure.rug.nl/ws/files/2384235/2013EncyclBiophysPoolman.pdf

Substrate Capture by ABC Transporters

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Proceedings - University of Groningen