Recent studies found that high glucose increases the expression of tumor suppressor factor p53. And in the process of diabetic kidney disease (DKD) development p53 involves in regulating multiple signaling pathways. In addition, microRNAs (miRNAs) involve in many diseases pathogenesis. And miRNAs affect DKD development via adjusting multiple mechanism. More importantly, p53/miRNAs signaling may participate in a variety of signaling pathways regulating kidney inflammation and fibrosis to control DKD pathological development. However, the mechanism of p53/miRNAs signaling participate in DKD pathological development is not yet clear. To illuminate the role of p53/miRNAs signaling may inspire a new thinking for elucidating the pathological mechanism of DKD, and provide a new theoretical basis for the prevention and treatment of DKD
