This study aims to familiarize the Romanian environment, but also the international one with the tradition of economic exchanges between Romania and the countries that make up Mercosur. The novelty lies in intercultural perspective that often proves determinant in the economical progress. Managers from different cultures, in this case those in Romania and those in South America, have specific ways to address the same type of problem. The knowledge of the differences between the two regions can be efficient for the beneficial growth of the economical exchanges. The article will be divided into two parts: the first part will appear in this issue and will include theoretical aspects on the economy of Mercosur countries and Romania, the management style and the particularities of intercultural management of the two areas, and in the next issue will be discussed the comparative analysis of the differences between the two areas and its importance, the motivations, characteristics and general considerations of the border collaborations. The hypothesis from which we started in making this essay is the following: between Romania and Mercosur countries exist distinct cultural specificity elements which affects the mutual economical exchanges and their development. Ethnic, historical, religious, communication, etc differences manifested in these countries can have an impact on the members of the international organizations generating attitudes between sellers on one hand and customers on the other. These positions against action can materialize in profit for some companies (countries) and poor performance for others. The purpose of the investigation is to analyze the elements of regional specificity of the four countries in South America and Romania, as well as the effect they had on the trade developments Romania-Mercosur. The interdisciplinary pragmatic model (Singer and Churchman) with holistic character is the reference in making this essay. The methodological system is constructivist, analyzing the subjective processes of the system and not just the noticeable behaviors, and the approach is mixed qualitative- quantitative