Farkas, Tamás

Juhász-Vedres, Gabriella

Kis, Zsolt

Rákos, Gabriella

Rózsa, Éva

Toldi, József

Wölfling, János

English

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Göttingen Meeting of the German Neuroscience Society 2007Dehydroepiandrosterone sulfate is neuroprotective in a focal cortical cold lesion modelTamas Farkas1, Gabriella Juhasz-Vedres1, Eva Rozsa1, Gabriella Rakos1, Zsolt Kis1,Janos Wolfling2 and Jozsef Toldi11Department of Comparative Physiology, University of Szeged, Kozep fasor 52, Szeged, Hungary2Department of Organic Chemistry, University of Szeged, Dom ter 8, Szeged, HungaryDehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors. They may function asneurotrophic or neuroprotective factors to protect central nervous system neurons against a variety of insults,including excitotoxicity. The present study evaluated the effects of DHEAS and 17beta-estradiol (E2) in afocal cortical cold lesion model, in which DHEAS and equimolar E2 were administered either as pretreatment(two injections 1 d and 1 h before lesion induction) or as posttreatment (immediately after lesion induction).The focal cortical cold lesion was induced in the primary motor cortex by means of a cooled copper cylinderplaced directly onto the cortical surface. One hour later, the animals were killed, the brains were cut into0.4-mm-thick slices, and the sections were stained with 1% triphenyltetrazolium chloride. The volume of thehemispheric lesion was calculated for each animal. The results demonstrated that the lesion area wassignificantly attenuated in both the DHEAS- and E2- pre- and posttreated groups and that, in the presence ofletrozole, a nonsteroidal aromatase inhibitor, no neuroprotection was observed, suggesting that the beneficialeffect of DHEAS on the cold injury might depend on the conversion of DHEAS to E2 within the brain. It isconcluded that even a single posttraumatic administration of DHEAS may be of substantial therapeutic benefitin the treatment of focal brain injury with vasogenic edema.Acknowledgments: The present study was supported by OTKA grants (T046687, F037407 and M36213),RET-08/2004, OMFB-00383/2005 and SK08/2004, GVOP-3.2.1. -2004-04-0357/3.0. T. F. is a Bolyai Fellowof the Hungarian Academy of Sciences.T35-15C

Dehydroepiandrosterone sulfate is neuroprotective in a focal cortical cold lesion model

Dehydroepiandrosterone sulfate is neuroprotective in a focal cortical cold lesion model

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