The neural crest is an excellent model system for the study of cell type diversification during embryonic development due
to its multipotency, motility, and ability to form a broad array of derivatives ranging from neurons and glia, to cartilage,
bone, and melanocytes. As a uniquely vertebrate cell population, it also offers important clues regarding vertebrate
origins. In the past 30 yr, introduction of recombinant DNA technology has facilitated the dissection of the genetic
program controlling neural crest development and has provided important insights into gene regulatory mechanisms
underlying cell migration and differentiation. More recently, new genomic approaches have provided a platform and
tools that are changing the depth and breadth of our understanding of neural crest development at a "systems" level. Such
advances provide an insightful view of the regulatory landscape of neural crest cells and offer a new perspective on
developmental as well as stem cell and cancer biology
