The rapid progress and development in machine-learning algorithms becomes a key factor in determining the future of humanity. These algorithms and techniques were utilized to solve a wide spectrum of problems extended from data mining and knowledge discovery to unsupervised learning and optimization. This dissertation consists of two study areas. The first area investigates the use of reinforcement learning and adaptive critic design algorithms in the field of power grid control. The second area in this dissertation, consisting of three papers, focuses on developing and applying clustering algorithms on biomedical data. The first paper presents a novel modelling approach for demand side management of electric water heaters using Q-learning and action-dependent heuristic dynamic programming. The implemented approaches provide an efficient load management mechanism that reduces the overall power cost and smooths grid load profile. The second paper implements an ensemble statistical and subspace-clustering model for analyzing the heterogeneous data of the autism spectrum disorder. The paper implements a novel k-dimensional algorithm that shows efficiency in handling heterogeneous dataset. The third paper provides a unified learning model for clustering neuroimaging data to identify the potential risk factors for suboptimal brain aging. In the last paper, clustering and clustering validation indices are utilized to identify the groups of compounds that are responsible for plant uptake and contaminant transportation from roots to plants edible parts --Abstract, page iv
