"Click" Approach to the Synthesis of 2,6-Bis(1,2,3-triazolyl)purine Deoxynucleosides
- Publication date
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- RTU Press
Abstract
Azide-alkyne 1,3-dipolar cycloaddition reaction (click reaction) has been found to be useful in nucleoside, nucleotide and oligonucleotide chemistry. In last years a number of 1,2,3-triazolylnucleoside derivatives have been synthesized and investigated, leading to discovery of substances with antiviral and anticancer activity, enzyme inhibitors, adenosine receptor agonists and antagonists