Let Us Protect Our Future is a sexual risk-reduction intervention for sixth-grade adolescents in South Africa. Tested in a cluster-randomized controlled trial, the intervention significantly reduced self-reported intercourse and unprotected intercourse during a 12-month follow-up period. The present analyses were conducted to identify moderators of the intervention\u27s efficacy as well as, which theory-based variables mediated the intervention\u27s effects. Intervention efficacy over the 3-, 6-, and 12-month follow-up was tested using generalized estimating equation models. Living with their father in the home, parental strictness, and religiosity moderated the efficacy of the intervention in reducing unprotected intercourse. Self-efficacy to avoid risky situations and expected parental disapproval of their having intercourse, derived from Social Cognitive Theory, significantly mediated the intervention\u27s effect on abstinence. This is the first study to demonstrate that Social Cognitive variables mediate the efficacy of a sexual risk-reduction intervention among South African adolescents. --author-supplied descriptio
