This paper examines how exploiting the hyperconnectivity and modularity concepts underpinning the Physical Internet enables the parcel logistics industry to meet the worldwide challenges to efficiently and sustainably offer faster and more precise deliveries across urban agglomerations, notably across the world’s megacities. It emphasizes disruptive transformations of package logistics hubs and networks, such as multi-tier world pixelization, multi-plane parcel logistics web, smart dynamic parcel routing and hub-based consolidation, and modular parcel containerization