呋喃妥因 (NFT)在 0 .1mol/LHAc NaAc (pH 4 .0 )溶液中于钴 /玻碳 (Co/GC)离子注入修饰电极上产生一灵敏的伏安还原峰 ,峰电位为 - 0 .2 6V(vs.Ag/AgCl) ,峰电流与NFT浓度在 6 .0× 10 -8～ 5 .0× 10 -6mol/L范围内呈线性关系 (r =0 .9987) ,检出限为 1.0× 10 -8mol/L。用线性扫描伏安法和循环伏安法研究了NFT的伏安行为、吸附特性和电极反应机理。测定了电子转移数 (n =4 )、转移系数 (α =0 .5 8)和参与反应的质子数 (X =4 )等电化学参数。结果表明该电极过程为一具有吸附性的不可逆过程。该法用于片剂中NFT含量的测定 ,得到满意的结果。用标准加入法测得该法的回收率为 94 .0 %～ 98.5 %。In 0.1 mol/L HAc-NaAc buffer (pH 4.0) solution, a sensitive reductive peak of nitrofurantion was obtained by linear sweep voltammetry on the cobalt/glassy carbon (Co/GC) ion implantation modified electrode. The peak potential was -0.26 V ( vs. Ag/AgCl). The linear range between the peak current and the concentration of nitrofurantoin was 6.0 x 10(-8) similar to5.0 x 10(-6) mol/L (r = 0.9987). The detection limit was 1.0 x 10(-8) mol/L. The voltammetric behaviour, adsorptive characteristic and the electrode reaction mechanism of nitrofarantoin were studied by means of linear sweep and cyclic voltammetry. Some electrochemical parameters such as electron transfer numbers (n = 4), electron transfer coefficient (alpha = 0.58) and proton numbers (X = 4) have been determined. The electrode reduction process of nitrofurantoin at Co/GC was irreversible with adsorptive characteristic. This method has been used to determine the content of nitrofurantoin in medical tablets. The recovery was determined to be 94.0% similar to 98.5% by means of standard addition method.广东省自然科学基金 (No .0 1110 5 ,0 3 15 77);广西壮族自治区自然科学基金 (No .0 14 10 3 7,0 3 42 0 18);广西民族学院引进人才启动基金 (No .OHHX0 0 0 0 2 )资助项
