用微量热法测定了大肠杆菌及其在Co(Ⅲ ) -SG配合物作用下的热谱曲线 ,计算了速率常数k ,传代时间G、抑制I、总产热量Q、单个细菌的产热量Q0 和每分钟单个细菌的产热量 Q0 ,建立了部分代谢参数之间的关系 ,探讨了大肠杆菌在不同温度和Co(Ⅲ ) -SG作用下的代谢抑制 ,发现可用t、tr、tg和 Q0 定量表征在不同温度下大肠杆菌的生长代谢和药物的抗菌活性 . The power -time curves of E .coli reacting with Co(Ⅲ)-SG at different temperature has been determined
by microcalorimtric method The multiplication rate constant k , generation time G, bacterial growth inhibition ratio I , total
thermogenetic quantity Q , the heat quantity of a single bacterium Q0 and the heat quantity of a single bacterium per
minute Q have also been calculated according to the power -time curves .On the basis of k ～ T data , the formula lnk
～ 1/ T has graphically obtained and activation energy Ea of bacterial growth and pre -exponetial factor A'have been
calculated.by graphing the parameters of E .coli growth metabolism , the relationships of tr ～ k , tg ～ k and t ～ k have
been derived .The paper provides a discussion about the growth metabolism of E .coli reacted upon by Schiff base Co
(Ⅲ)complex at different temperatures, and it is found that tr , tg , t and Q0 can be used to characterize bacterial growth
metabolism and the antibacterial activity of drugs at different tmperature
