Atzori, Manuela

De Montis, Antonella

Maxia, Cristina

Minerba, Luigi

Murtas, Daniela

Perra, Maria Teresa

Piga, Michela

Piras, Franca

Pittau, Marco

Sirigu, Paola

Firenze University Press: E-Journals

IJAE Vol. 115, n. 1/2 (Supplement), 2010
140
Human papillomavirus type distribution and 
correlation with cyto-histological patterns in women 
from benin
Franca Piras1, Michela Piga2, Antonella De Montis3, Manuela Atzori3, Marco Pittau4, Daniela Murtas1, 
Luigi Minerba5, Cristina Maxia1, Maria Teresa Perra1, Paola Sirigu1
1 Department of Cytomorphology, University of Cagliari, Italy 
2 Department of Pathology, ‘SS. Trinità’ Hospital, Cagliari, Italy 
3 Research Laboratories, bcs Biotech, Cagliari, Italy 
4 Cloning Laboratory, bcs Biotech S.p.A., Cagliari, Italy 
5 Department of Public Health, University of Cagliari, Italy
Benin has a population of 2.22 millions women ages 15 years and older who are at 
risk of developing cervical cancer. Current estimates indicate that every year 561 women 
are diagnosed with cervical cancer and 448 die from the disease. Cervical cancer ranks 
as the 2nd most frequent cancer among women in Benin, and the 2nd most frequent 
cancer among women between 15 and 44 years of age. Human papillomavirus (HPV) 
infection is now a well-established cause of cervical cancer. Data is not yet available on 
the HPV burden in the general population of Benin.
This report, for the first time, provides informations for Benin on HPV-related statis-
tics and cervical cancer screening practices.
Human papillomavirus (HPV) type-specific distribution was evaluated in cervical 
swabs collected from 725 women from the Benin undergoing voluntary screening and 
correlated with cyto-histological abnormalities. Only 351 samples were valuable for 
HPV DNA detection and 493 for PAP test. HPV DNA was detected in 35% of the sam-
ples, 90% of which had high-risk HPV infection, 36% multiple infection, and 64% single 
infection. HPV types 16 and 18 are responsible for about 70% of all cervical cancer cases 
worldwide. Our data show that in Benin the most common high risk HPV types were 
HPV-59 (26%) and HPV-16 (19%), followed by HPV-35 (16%), HPV-18 (15%), HPV-58 
(11%), HPV-45 (9%), HPV-56 (7%), HPV-73 (6%), HPV-51 (3%), HPV-31, -33, -52 (2%) in 
women with both normal and abnormal cytology. 
Key words
Human papilloma virus, cervical lesions


Human papillomavirus type distribution and correlation with cyto-histological patterns in women from Benin

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Human papillomavirus type distribution and correlation with cyto-histological patterns in women from Benin

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