Bandiera, Pasquale

Curreli, Eleonora

Dettori, Serena

Ena, Pasquale

Mazzarello, Vittorio

Montella, Andrea

Pirino, Alessio

Piu, Luisella

Firenze University Press: E-Journals

IJAE Vol. 115, n. 1/2 (Supplement), 2010
109
Lip Plumper: non invasive in vitro study of moisturizing 
and volumizing effect
Vittorio Mazzarello1, Pasquale Bandiera1, Pasquale Ena2, Luisella Piu3, Serena Dettori1, Eleonora Cur-
reli1, Alessio Pirino1, Andrea Montella1
1 Department of Biomedical Science, University of Sassari, Italy
2 Institute of Dermatology, University of Sassari, Italy
3 Department of Drug Sciences, University of Sassari, Italy
Objective This experimental study was conducted with the aim of applying the non-
invasive techniques to evaluate the hydrating and volumizing effect of a commercial lip 
plumper officinalis ginger oil and sodium hyaluronate based within one hour after its 
application. 
Materials And Methods We recruited 20 normal healthy women, older than 18 
years, with negative clinical history for aesthetic operations on the lips, rosacea and 
atopy, without lip diseases in the last month and taken drugs or topical therapy in last 
week. The experimental design was developed through a baseline phase, corresponding 
to the time preceding treatment, T1, T2, T3, stages of short term tests, corresponding to 
15’, 30’ and an hour after the application of product. 
The parameters evaluated for both the baseline phase and the phase of short term tests 
were: the effect on increasing hydration by Corneometer CM820, the effect on increas-
ing blood flow by Mexameter MX16, anthropometric measures 2D by 6-point marker of 
soft tissue with evaluation of distances on digital macrophotography and image analysis 
technique using 3D replica lip at SEM by MEX software for 3D analysis. Statistical analy-
sis was done using the ANOVA method, p<0.05 was considered significant. 
Results And Conclusion The sodium hyaluronate present in the product at issue 
led to a statistically significant increase in values of hydration of 22.2% compared to 
baseline with a peak after the first 15’-30’. Officinalis ginger oil is an irritant to mucous 
membranes, manifested by vasodilation, resulted in a statistically significant increase 
after the first 15’ that has kept this up to 30’ and then decreased in intensity. The mucosa 
was analyzed in the points raised by about 0.5 mm in the first 15’-30’ from the product of 
a complete absence of side effects delayed. Regarding the volumizing effect parameters 
2D show an increase in the early 30’ but the values were not statistically significant at all 
times analyzed; parameters 3D has seen an increase of the maximum protrusion of the 
vermilion after 15’ product application and then decreased in intensity. 
The cosmetic effect was found for 35% of the volunteers between sufficient and good 
and 65% low compared to expectations.
Key words
Lip, non invasive analysis, 3D image analysis.


Lip Plumper: non invasive in vitro study of moisturizing and volumizing effect

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Lip Plumper: non invasive in vitro study of moisturizing and volumizing effect

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