Drug Release through PEG-Xanthan Gum-Lactose Matrix Comprising Different Amount of Drug

Abstract

Objective: The purpose of this study is to investigate the effect of xanthan gum and lactose on the physical and releaseproperties of 25-mg and 75-mg indomethacin tablets containing polyethylene glycol (PEG) prepared by mold technique. Method:The physical and drug release characteristics of developed matrix tablet were studied. Least square fitting the experimentaldissolution data to the mathematical expressions (power law, first order, Higuchi’s and zero order) was carried out. Results:Because of the more completion dissolution of drug in PEG matrix, the drug release from the lower-drug loading tablet wasfaster than the higher-drug loading tablet. An addition of xanthan gum could sustain the drug release whereas an addition oflactose diminished the drug dissolution. From curve fitting, most drug release profiles were primarily as Fickian diffusion.Conclusion: Amount of indomethacin played an important role on the drug released from PEG matrix consisting xanthan gumand lactose prepared with fusion and mold technique. Xanthan gum and lactose also affected the physical and releasecharacteristics of these investigated indomethacin tablets.Keywords: Characterization, drug, release, mold tablet, hydroxypropyl methylcellulose, polyethylene glycolThai Pharm Health Sci J 2009;4(2):153-163