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Progressive multifocal leukoencephalopathy - Epidemiology, immune response, clinical differences, treatment
Authors
Lenka Fašaneková
Kateřina Havlíčková
+7 more
Petr Husa
Matúš Mihalčin
Petr Snopek
Svatava Snopková
Radek Svačinka
Pavlína Volfová
Petr Štourač
Publication date
19 September 2019
Publisher
Czech Medical Association J.E. Purkyne
Abstract
Progressive multifocal leukoencephalopathy (PML) is a severe disease of the central nervous system with very high mortality. It is caused by the JC virus with high seroprevalence, at up to 80%. Development of PML is typically opportunistic, particularly in acquired immunodeficiency syndrome, and usually affects patients with profound immunodeficiency. Furthermore, as a result of highly efficient immunosuppressive and immunomodulatory treatments in recent years, the number of PML cases has increased in the general population. In this article, the authors mention virological and epidemiological relationships and characteristic manifestations of PML. Possible relationships of humoral and cellular immunity are discussed and limited treatment options including prophylaxis are mentioned. © 2019, Czech Medical Association J.E. Purkyne. All rights reserved
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Last time updated on 17/10/2019